Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice
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Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Xuebing Ding, Zhi Xiang, Chi Qin, Yongkang Chen, Haiyan Tian, Lin Meng, Danhao Xia, Han Liu, Jia Song, Jun Fu, Mingming Ma, Xuejing Wang;Xuebing Ding;Zhi Xiang;Chi Qin;Yongkang Chen;Haiyan Tian;Lin Meng;Danhao Xia;Han Liu;Jia Song;Jun Fu;Mingming Ma;Xuejing Wang;
acta neuropathologica communications 2021 Vol. 9 pp. -
163
wang2021actaspreading

Abstract

Transactive response DNA-binding protein 43 kDa (TDP-43) has been identified as the major component of ubiquitinated inclusions found in patients with sporadic amyotrophic lateral sclerosis (ALS). Increasing evidence suggests prion-like ...

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DOI:
10.1186/s40478-020-01112-3
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC78145...

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