Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain
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Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

Joanna J. Bury, Annabelle Chambers, Paul R. Heath, Paul G. Ince, Pamela J. Shaw, Fiona E. Matthews, Carol Brayne, Julie E. Simpson, Stephen B. Wharton, the Cognitive Function and Ageing Study;Joanna J. Bury;Annabelle Chambers;Paul R. Heath;Paul G. Ince;Pamela J. Shaw;Fiona E. Matthews;Carol Brayne;Julie E. Simpson;Stephen B. Wharton;the Cognitive Function and Ageing Study;
acta neuropathologica communications 2021 Vol. 9 pp. -
127
study2021actatype

Abstract

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, ...

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DOI:
10.1186/s40478-020-01109-y
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC77888...

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