Phosphorylated CREB binds specifically to the nuclear protein CBP
Abstract
Cyclic AMP-regulated gene expression frequently involves a DNA element known as the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. This modification stimulates interact …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Molecular
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
amino acid sequence
P.H.S.
cell line
DNA
Genes
Nuclear Proteins / metabolism*
Transcription Factors / metabolism*
Base Sequence
Molecular Sequence Data
recombinant fusion proteins / genetics
cyclic amp-dependent protein kinases / metabolism
cloning
protein binding
phosphorylation
reporter
binding sites
recombinant fusion proteins / metabolism
gene expression regulation / physiology
creb-binding protein
trans-activators*
cyclic amp response element-binding protein / genetics
cyclic amp response element-binding protein / metabolism*
pmid:8413673
doi:10.1038/365855a0
j c chrivia
r p kwok
r h goodman
cyclic amp / physiology
thyroid gland / metabolism
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270516
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