Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer
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Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer

Michelangelo Fiorentino, Giorgia Zadra, Emanuele Palescandolo, Giuseppe Fedele, Dyane Bailey, Christopher Fiore, Paul L. Nguyen, Toshiro Migita, Raffaella Zamponi, Dolores Di Vizio, Carmen Priolo, Sharma Chandan, Wanling Xie, Martin E. Hemler, Lorelei Mucci, Edward Giovannucci, Stephen Finn, Massimo Loda;Michelangelo Fiorentino;Giorgia Zadra;Emanuele Palescandolo;Giuseppe Fedele;Dyane Bailey;Christopher Fiore;Paul L. Nguyen;Toshiro Migita;Raffaella Zamponi;Dolores Di Vizio;Carmen Priolo;Sharma Chandan;Wanling Xie;Martin E. Hemler;Lorelei Mucci;Edward Giovannucci;Stephen Finn;Massimo Loda;
laboratory investigation; a journal of technical methods and pathology 2008 Vol. 88 pp. 1340-
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loda2008laboratoryoverexpression

Abstract

Fatty acid synthase (FASN), a key metabolic enzyme for liponeogenesis highly expressed in several human cancers, displays oncogenic properties such as resistance to apoptosis and induction of proliferation when overexpressed. To date, no mechanism has ...

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DOI:
10.1038/labinvest.2008.97
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC322373...

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