RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

Lee JY;Ristow M;Lin X;White MF;Magnuson MA;Hennighausen L;;
The Journal of biological chemistry 2006 Vol. 281 pp. -
228
jy2006therip-cre

Abstract

The Cre/loxP recombinase system for performing conditional gene targeting experiments has been very useful in exploring genetic pathways that control both the development and function of pancreatic beta-cells. One particular line of transgenic mice (B6.Cg-Tg(Ins2-cre)25Mgn/J), commonly called RIP-Cr …

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