Disruption of the ARF–Mdm2–p53 tumor suppressor pathway in Myc-induced lymphomagenesis
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Disruption of the ARF–Mdm2–p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Christine M. Eischen, Jason D. Weber, Martine F. Roussel, Charles J. Sherr, John L. Cleveland;Christine M. Eischen;Jason D. Weber;Martine F. Roussel;Charles J. Sherr;John L. Cleveland;
genes & development 1999 Vol. 13 pp. 2658-
147
cleveland1999genesdisruption

Abstract

Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Eμ) develop B-cell lymphoma and exhibit a mean survival time of approximately 6 months. The protracted latent period before the onset of frank disease ...

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DOI:
10.1101/gad.13.20.2658
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC317106...

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