A polymorphic DNA marker genetically linked to Huntington's disease - Nature

A polymorphic DNA marker genetically linked to Huntington's disease - Nature

Gusella, James F.;Wexler, Nancy S.;Conneally, P. Michael;Naylor, Susan L.;Anderson, Mary Anne;Tanzi, Rudolph E.;Watkins, Paul C.;Ottina, Kathleen;Wallace, Margaret R.;Sakaguchi, Alan Y.;Young, Anne B.;Shoulson, Ira;Bonilla, Ernesto;Martin, Joseph B.;Gusella, James F.;Wexler, Nancy S.;Conneally, P. Michael;Naylor, Susan L.;Anderson, Mary Anne;Tanzi, Rudolph E.;Watkins, Paul C.;Ottina, Kathleen;Wallace, Margaret R.;Sakaguchi, Alan Y.;Young, Anne B.;Shoulson, Ira;Bonilla, Ernesto;Martin, Joseph B.;
Nature 1970 Vol. 306 pp. 234-238
165
f.1970naturea

Abstract

Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.

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