Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
Fabio Silvio Taccone, Pierre-François Laterre, Herbert Spapen, Thierry Dugernier, Isabelle Delattre, Brice Layeux, Daniel De Backer, Xavier Wittebole, Pierre Wallemacq, Jean-Louis Vincent, Frédérique Jacobs;Fabio Silvio Taccone;Pierre-François Laterre;Herbert Spapen;Thierry Dugernier;Isabelle Delattre;Brice Layeux;Daniel De Backer;Xavier Wittebole;Pierre Wallemacq;Jean-Louis Vincent;Frédérique Jacobs;
critical care2010Vol. 14pp. R53-
165
jacobs2010criticalrevisiting
Abstract
It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased volume of distribution (V[d] ), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 ...