Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock

Fabio Silvio Taccone, Pierre-François Laterre, Herbert Spapen, Thierry Dugernier, Isabelle Delattre, Brice Layeux, Daniel De Backer, Xavier Wittebole, Pierre Wallemacq, Jean-Louis Vincent, Frédérique Jacobs;Fabio Silvio Taccone;Pierre-François Laterre;Herbert Spapen;Thierry Dugernier;Isabelle Delattre;Brice Layeux;Daniel De Backer;Xavier Wittebole;Pierre Wallemacq;Jean-Louis Vincent;Frédérique Jacobs;
critical care 2010 Vol. 14 pp. R53-
165
jacobs2010criticalrevisiting

Abstract

It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased volume of distribution (V[d] ), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 ...

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