Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
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Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan;Lauren V. C. Miller;Aamir S. Mukadam;Claire S. Durrant;Marina J. Vaysburd;Taxiarchis Katsinelos;Benjamin J. Tuck;Sophie Sanford;Olivia Sheppard;Claire Knox;Shi Cheng;Leo C. James;Michael P. Coleman;William A. McEwan;
acta neuropathologica communications 2021 Vol. 9 pp. -
90
mcewan2021actatau

Abstract

A fundamental property of infectious agents is their particulate nature: infectivity arises from independently-acting particles rather than as a result of collective action. Assemblies of the protein tau can exhibit seeding behaviour, potentially underlying ...

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DOI:
10.1186/s40478-021-01141-6
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79537...

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