Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection
Abstract
Influenza is a highly infectious disease characterized by recurrent annual epidemics and unpredictable major worldwide pandemics. Rapid spread of the highly pathogenic avian H5N1 strain and escalating human infections by the virus have set off the alarm for a global pandemic. To provide an urgently …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
female
N.I.H.
Extramural
cell line
Inbred BALB C
dogs
antiviral agents / pharmacology*
influenza
virus replication / drug effects
human / drug therapy
ferrets
orthomyxoviridae / drug effects*
pmid:16569867
pmc1426979
doi:10.1128/aac.50.4.1470-1479.2006
michael p malakhov
laura m aschenbrenner
fang fang
amphiregulin
bacterial adhesion / drug effects
catalytic domain
egf family of proteins
glycoproteins / pharmacology*
intercellular signaling peptides and proteins / pharmacology*
neuraminidase / chemistry
neuraminidase / pharmacology*
peptide fragments / pharmacology*
recombinant fusion proteins / isolation & purification
recombinant fusion proteins / pharmacology*
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269180
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