A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity

A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity

Natalia J. Martinez, Maria C. Ow, M. Inmaculada Barrasa, Molly Hammell, Reynaldo Sequerra, Lynn Doucette-Stamm, Frederick P. Roth, Victor R. Ambros, Albertha J.M. Walhout;Natalia J. Martinez;Maria C. Ow;M. Inmaculada Barrasa;Molly Hammell;Reynaldo Sequerra;Lynn Doucette-Stamm;Frederick P. Roth;Victor R. Ambros;Albertha J.M. Walhout;
genes & development 2008 Vol. 22 pp. 2535-
151
walhout2008genesa

Abstract

MicroRNAs (miRNAs) and transcription factors (TFs) are primary metazoan gene regulators. Whereas much attention has focused on finding the targets of both miRNAs and TFs, the transcriptional networks that regulate miRNA expression remain largely unexplored. ...

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