National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male N.I.H. Extramural Disease Models animal* mutation nude receptor pmid:29786783 pmc6203618 doi:10.1007/s10456-018-9624-7 jillian goines xian li elisa boscolo class i phosphatidylinositol 3-kinases / genetics class i phosphatidylinositol 3-kinases / metabolism heterografts human umbilical vein endothelial cells* / metabolism human umbilical vein endothelial cells* / pathology human umbilical vein endothelial cells* / transplantation tie-2 / genetics tie-2 / metabolism vascular malformations* / genetics vascular malformations* / metabolism vascular malformations* / pathology