Maternal Citicoline-Supplemented Diet Improves the Response of the Immature Hippocampus to Perinatal Asphyxia in Rats

Maternal Citicoline-Supplemented Diet Improves the Response of the Immature Hippocampus to Perinatal Asphyxia in Rats

Sebastian Isac;Anca Maria Panaitescu;Mara Ioana Iesanu;Vlad Zeca;Natalia Cucu;Leon Zagrean;Gheorghe Peltecu;Ana-Maria Zagrean;
neonatology 2020 Vol. 117 pp. 729-735
147
isac2020neonatologymaternal

Abstract

Background: Citicoline represents a dietary source of choline, an essential nutrient, and precursor of cell membrane components, highly required during development and post-injury recovery. Objectives: We previously showed that perinatal asphyxia (PA) induces hippocampal neuroinflammation and injury that are subject to epigenetic change by maternal

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