Maternal Citicoline-Supplemented Diet Improves the Response of the Immature Hippocampus to Perinatal Asphyxia in Rats
Sebastian Isac;Anca Maria Panaitescu;Mara Ioana Iesanu;Vlad Zeca;Natalia Cucu;Leon Zagrean;Gheorghe Peltecu;Ana-Maria Zagrean;
neonatology2020Vol. 117pp. 729-735
147
isac2020neonatologymaternal
Abstract
Background: Citicoline represents a dietary source of choline, an essential nutrient, and precursor of cell membrane components, highly required during development and post-injury recovery. Objectives: We previously showed that perinatal asphyxia (PA) induces hippocampal neuroinflammation and injury that are subject to epigenetic change by maternal