National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Molecular Inbred C57BL RNA animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't male exons P.H.S. Cells Cultured plasmids polymerase chain reaction Immunoblotting Body Weight DNA-Binding Proteins / metabolism* Nuclear Proteins / metabolism* Receptors Liver / pathology DNA-Binding Proteins / genetics* Gene Expression Regulation* Liver / metabolism* Nuclear Proteins / genetics* transcription messenger / metabolism electrophoresis transgenic cloning nucleic acid hybridization blotting messenger / analysis transfection alternative splicing triglycerides / metabolism isomerism down-regulation northern cell nucleus / metabolism transcription factors* sterol regulatory element binding protein 1 biological transport polyacrylamide gel j l goldstein ccaat-enhancer-binding proteins* pmid:9062341 PMC507891 doi:10.1172/JCI119248 H Shimano J D Horton Acetyl-CoA Carboxylase / genetics Acetyl-CoA Carboxylase / metabolism Cholesterol / metabolism DNA-Binding Proteins / immunology Fatty Acid Synthases / genetics Fatty Acid Synthases / metabolism Glyceraldehyde-3-Phosphate Dehydrogenases / analysis Luciferases / metabolism Nuclear Proteins / immunology LDL / genetics LDL / metabolism Ribonucleases / metabolism