Blunted fasting-induced hypothalamic activation and refeeding hyperphagia in late-onset obesity
Abstract
Hormonal and metabolic factors signal the status of energy balance to hypothalamic nuclei. Obesity is characterized by neuronal, metabolic and hormonal alterations. We therefore hypothesized that hypothalamic responses to challenges of energy balance may differ between lean and obese animals. To tes …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
transgenic
age of onset
green fluorescent proteins / genetics
hyperinsulinism / physiopathology
obesity / physiopathology*
neurons / physiology
intracellular signaling peptides and proteins / metabolism
blood glucose / physiology
pmid:19844081
doi:10.1159/000251723
csilla becskei
thomas a lutz
thomas riediger
arcuate nucleus of hypothalamus / physiopathology*
fasting / physiology*
hyperphagia / physiopathology*
hypothalamic area
lateral / physiopathology*
leptin / blood
melanins / metabolism
neuropeptide y / metabolism
neuropeptides / metabolism
orexins
paraventricular hypothalamic nucleus / physiopathology*
proto-oncogene proteins c-fos / metabolism
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268384
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