Transient prenatal androgen exposure produces metabolic syndrome in adult female rats
Abstract
Androgen exposure during intrauterine life in nonhuman primates and in sheep results in a phenocopy of the reproductive and metabolic features of polycystic ovary syndrome (PCOS). Such exposure also results in reproductive features of PCOS in rodents. We investigated whether transient prenatal andro …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
female
N.I.H.
Extramural
Rats
Sprague-Dawley
liver / metabolism
testosterone / pharmacology*
polycystic ovary syndrome / metabolism
body weight / drug effects
glucose tolerance test
insulin resistance / physiology*
signal transduction
insulin / blood
triglycerides / blood
prenatal exposure delayed effects
muscle
skeletal / metabolism
adipose tissue / drug effects
metabolic syndrome / metabolism*
cholesterol / blood
pmid:18544644
pmc2519755
doi:10.1152/ajpendo.90208.2008
marek demissie
milos lazic
jon e levine
dietary fats / metabolism
Citation
ID:
268256
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