Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial
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Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial

Elie Azoulay, Virginie Lemiale, Djamel Mokart, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Lilia Berrahil-Meksen, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet, Achille Kouatchet, Vincent Peigne, Igor Théodose, Pierre Perez, Christophe Girault, Samir Jaber, Johanna Oziel, Martine Nyunga, Nicolas Terzi, Lila Bouadma, Christine Lebert, Alexandre Lautrette, Naike Bigé, Jean-Herlé Raphalen, Laurent Papazian, Michael Darmon, Sylvie Chevret, Alexandre Demoule;Elie Azoulay;Virginie Lemiale;Djamel Mokart;Saad Nseir;Laurent Argaud;Frédéric Pène;Loay Kontar;Fabrice Bruneel;Kada Klouche;François Barbier;Jean Reignier;Lilia Berrahil-Meksen;Guillaume Louis;Jean-Michel Constantin;Julien Mayaux;Florent Wallet;Achille Kouatchet;Vincent Peigne;Igor Théodose;Pierre Perez;Christophe Girault;Samir Jaber;Johanna Oziel;Martine Nyunga;Nicolas Terzi;Lila Bouadma;Christine Lebert;Alexandre Lautrette;Naike Bigé;Jean-Herlé Raphalen;Laurent Papazian;Michael Darmon;Sylvie Chevret;Alexandre Demoule;
JAMA 2018 Vol. 320 pp. 2099-
136
demoule2018jamaeffect

Abstract

In immunocompromised patients with acute hypoxemic respiratory failure, is high-flow nasal oxygen therapy superior to standard oxygen therapy with respect to mortality at day 28?In this randomized clinical trial that included 776 critically ill immunocompromised ...

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DOI:
10.1001/jama.2018.14282
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65835...

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