17β-estradiol inhibits hepatic iNOS via the activation of the estrogen receptor ER-α and inhibition of erk1/2-mir-221 axis
Abstract
17β-Estradiol (E2) is known to negatively regulate inducible nitric oxide (NO) synthase (iNOS) expression via estrogen receptor alpha (ER-α) activation in aortic vascular smooth muscle cells.Therefore, we sought to determine whether E2 can inhibit iNOS in vivo in hepatic tissue via the activa …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
male
Rats
liver / drug effects
wistar
micrornas / genetics*
estradiol / pharmacology*
pmid:30574741
a panic
j stanimirovic
e r isenovic
estrogen receptor alpha / metabolism*
liver / enzymology*
map kinase signaling system*
nitric oxide synthase type ii / metabolism*
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