Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements

Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements

Richard Francis, Christine Richardson;Richard Francis;Christine Richardson;
genes & development 2007 Vol. 21 pp. 1064-
126
richardson2007genesmultipotent

Abstract

Chromosomal translocations are a hallmark of hematopoietic malignancies. The initial molecular events or pathways that lead to translocations in hematopoietic cells are largely unknown, particularly in the stem cell-enriched population postulated to be ...

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