Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants
Abstract
RWJ-270201 is a novel cyclopentane inhibitor of influenza A and B virus neuraminidases (NAs). We compared the ability of RWJ-270201 to inhibit NA activity of clinical influenza isolates and viruses with defined resistance mutations with that of zanamivir and oseltamivir carboxylate. In NA inhibition …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
Comparative Study
P.H.S.
drug resistance
microbial
enzyme inhibitors / pharmacology*
antiviral agents / pharmacology*
substrate specificity
cyclopentanes / pharmacology*
influenza a virus / drug effects
pmid:11709315
pmc90844
doi:10.1128/aac.45.12.3403-3408.2001
l v gubareva
r g webster
f g hayden
acetamides / pharmacology*
acids
carbocyclic
guanidines
influenza b virus / drug effects
neuraminidase / antagonists & inhibitors*
neuraminidase / metabolism
orthomyxoviridae / drug effects*
oseltamivir
pyrans
sialic acids / pharmacology*
zanamivir
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Citation
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267165
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