PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations
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PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations

Laura di Blasio, Alberto Puliafito, Paolo Armando Gagliardi, Valentina Comunanza, Desiana Somale, Giulia Chiaverina, Federico Bussolino, Luca Primo;Laura di Blasio;Alberto Puliafito;Paolo Armando Gagliardi;Valentina Comunanza;Desiana Somale;Giulia Chiaverina;Federico Bussolino;Luca Primo;
Cell death & disease 2018 Vol. 9 pp. -
121
primo2018cellpi3k/mtor

Abstract

Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. ...

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DOI:
10.1038/s41419-017-0064-x
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC583344...

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