In this study, the presence of polycyclic aromatic hydrocarbons (PAHs) was studied in indoor air (PM10) and settled dust collected from different indoor microenvironments of Saudi Arabia. Limited data is available on the indoor quality of Saudi Arabia and to the best of our knowledge, this is the first study reporting PAHs in indoor air from Saudi Arabia. The main objectives were to study the levels and profile of selected PAHs in indoor dust and PM10 samples from different microenvironments of Saudi Arabia and to estimate health risk assessment to the local population via inhalation, dust ingestion and dermal contact. To study PAHs, indoor dust and PM10 samples were collected from different households, offices and hotel roomsPM10.Pyrene, benz(a)anthracene, chrysene, and phenanthrene were the major PAHs in both settled dust and PM10 samples. Profile of PAHs in dust samples was dominated by 3 and 4 ring PAHs while in PM10 sample 5-6 aromatic ring PAHs also contributed significantly. PM10 collected from kitchens and AC filter dust samples were the most contaminated with PAHs. PM10Health risk assessment was made for adults and young based on benzo(a)pyrene equivalent carcinogenic power (BaPE) and incremental lifetime cancer risk (ILCR). BaPE revealed major toxicity threat associated with PAHs is all microenvironments samples (dust and PM10) is from 5 and 6 aromatic rings PAHs. ILRC calculated using ingestion, inhalation and dermal contact was within the limits set by USEPA and although using max concentration it was up to 8.0E-05, which can have significant impact long term if other exposure pathways such as food and outdoor exposure, etc. are considered.