Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
Abstract
Wnt/beta-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. Beta-catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss t …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
N.I.H.
Extramural
signal transduction*
cell adhesion
neoplasms / metabolism*
neoplasms / etiology
cilia / metabolism
beta catenin / metabolism*
pmid:19365405
doi:10.1038/cr.2009.41
shih-lei lai
andy j chien
randall t moon
cytoskeleton / metabolism*
frizzled receptors / metabolism*
wnt proteins / metabolism*
rho gtp-binding proteins / metabolism
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266870
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