Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody.

Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody.

McIntyre, K W;Stepan, G J;Kolinsky, K D;Benjamin, W R;Plocinski, J M;Kaffka, K L;Campen, C A;Chizzonite, R A;Kilian, P L;
journal of experimental medicine 1991 Vol. 173 pp. 931-939
221
w1991journalinhibition

Abstract

Recombinant human interleukin 1 receptor antagonist (IL-1ra) and 35F5, a neutralizing monoclonal antibody (mAb) to the type I mouse IL-1 receptor, were examined

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