MicroRNA-181c Inhibits Interleukin-6-mediated Beta Cell Apoptosis by Targeting TNF-α Expression
Abstract
We have previously reported that long-term treatment of beta cells with interleukin-6 (IL-6) is pro-apoptotic. However, little is known about the regulatory mechanisms that are involved. Therefore, we investigated pro-apoptotic changes in mRNA expression in beta cells in response to IL-6 treatment. …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
yoon sin oh
hee-sook jun
Rats
cell line
Gene Expression Regulation*
micrornas / metabolism*
apoptosis
insulin-secreting cells / metabolism*
pmid:30974824
pmc6480349
doi:10.3390/molecules24071410
gong deuk bae
insulin-secreting cells / cytology
interleukin-6 / metabolism*
tumor necrosis factor-alpha / biosynthesis*
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266662
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