NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway

NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway

Marie Frank-Vaillant, Stéphane Marcand;Marie Frank-Vaillant;Stéphane Marcand;
genes & development 2001 Vol. 15 pp. 3005-
132
marcand2001genesnhej

Abstract

In the yeast Saccharomyces cerevisiae, DNA double strand break (DSB) repair by nonhomologous end-joining (NHEJ) requires the DNA end-binding heterodimer Yku70p–Yku80p and the ligase Dnl4p associated with its cofactor Lif1p. NHEJ efficiency is ...

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