The Gravity Recovery and Climate Experiment (GRACE) mission has measured total water storage change (TWSC) and interpreted drought patterns in an unparalleled way since 2002. Nevertheless, there are few sources that can be used to understand drought patterns prior to the GRACE era. In this study, we extended the gridded GRACE TWSC to 1993 by combining principal component analysis (PCA), least square (LS) fitting, and multiple linear regression (MLR) methods using climate variables as input drivers. We used the extended (climate-driven) TWSC to interpret drought patterns (1993–2019) over the Amazon basin. Results showed that, in the Amazon area with the resolution of 0.5°, GRACE, GRACE follow on, and Swarm had correlation coefficients of 0.95, 0.92, and 0.77 compared with climate-driven TWSCS, respectively. The drought patterns assessed by the climate-driven TWSC were consistent with those interpreted by the Palmer Drought Severity Index and GRACE TWSC. We also found that the 1998 and 2016 drought events in the Amazon, both induced by strong El Niño events, showed similar drought patterns. This study provides a new perspective for interpreting long-term drought patterns prior to the GRACE period.