Recent progress in research on beta-cell apoptosis by cytokines
Abstract
Pancreatic beta-cell apoptosis plays a critical role in the pathogenesis of type 1 diabetes mellitus. As death effector molecules, perforin, Fas ligand, tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1, interferon (IFN)-gamma, and nitric oxide have been claimed. Recently, combinations or synerg …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
review
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
diabetes mellitus
up-regulation
type 1 / physiopathology
pmid:19273093
doi:10.2741/3271
kyoung-ah kim
myung-shik lee
apoptosis / physiology*
cytokines / physiology*
islets of langerhans / cytology*
nf-kappa b / physiology
stat1 transcription factor / physiology
x-linked inhibitor of apoptosis protein / physiology
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