Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus
Abstract
The mortality of human infection by influenza A/H5N1 virus can exceed 80%. The high mortality and its poor response to the neuraminidase inhibitor oseltamivir have been attributed to uncontrolled virus-induced cytokine storm. We challenged BALB/c mice with 1,000 LD50 of influenza A/Vietnam/1194/04. …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
Inbred BALB C
Survival Analysis
lung / pathology
time factors
survival rate
antiviral agents / therapeutic use*
body weight / drug effects
viral load
antiviral agents / pharmacology
influenza a virus
lung / virology
lymphocyte count
kwok-yung yuen
t-lymphocytes / drug effects
pmid:18523003
pmc2430364
doi:10.1073/pnas.0711942105
bo-jian zheng
kwok-wah chan
albumins / metabolism
chemokines / metabolism
immunologic factors / pharmacology
immunologic factors / therapeutic use*
h5n1 subtype / drug effects
h5n1 subtype / physiology*
lung / drug effects
orthomyxoviridae infections / drug therapy*
prostaglandins / metabolism
t-lymphocytes / virology
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