Botulinum toxin: chemistry, pharmacology, toxicity, and immunology

Botulinum toxin: chemistry, pharmacology, toxicity, and immunology

Brin MF;;
Muscle & nerve. Supplement 1997 Vol. 6 pp. -
131
mf1997musclebotulinum

Abstract

The seven serotypes of botulinum toxin (BTX) produced by Clostridium botulinum exert their paralytic effect by inhibiting acetylcholine release at the neuromuscular junction. Each of these zinc endopeptidases cleaves one or more proteins involved in vesicle transport and membrane fusion. The extent …

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