The paper indicates the importance of spatial planning as a specific instrument for the protection and management of World Heritage sites in Serbia. The paper analyses the obligations set forth in the international and national documents and legislation relevant for spatial planning, on the one hand, and World Heritage protection, on the other hand. The notion, criteria, method of zoning, systems and approaches to the management of sites inscribed on the World Heritage List are shown through the concept of World Heritage. The paper also emphasizes the importance of adopting management plans for all World Heritage sites and their incorporation into the national legislation and planning documents, primarily into the special purpose area spatial plans. It also gives examples of special purpose spatial plans in order to consider the treatment of World Heritage in these documents, and to make proposals for improving the spatial planning and the existing protection and management of the World Heritage sites in Serbia. [Projekat Ministarstva nauke Republike Srbije, br. TR36016: Sustainable spatial development of Danubian Serbia]