Objective: This study was performed with the aim of determining the relationship between personality dimensions, risk perception and coping strategies in people living with HIV (PLWH) in a Voluntary Counseling and Testing (VCT) center in Imam Khomeini Hospital and Karaj in 2016. Methods: The research sample size consisted of 100 (52 female and 48 male) PLWH who visited the VCT center and completed short neo-form tests, the Bentin risk perception, and the Lazarus-Folkman coping strategies test. Results: Problem-focused coping strategy had a positive correlation with extroversion personality dimensions (r = 0.46; P = 0.01), agreeableness (r = 0.36; P = 0.01), and conscientiousness (r = 0.39; P = 0.01). Moreover, risk perception showed a negative correlation with neuroticism (r = -0.28; P = 0.01), while it showed a positive significant correlation with extroversion (r = 0.30; P = 0.01), agreeableness (r = 0.40; P = 0.01), and conscientiousness (r = 0.34; P = 0.01). There was a statistically significant relationship between risk perception and personality dimensions (P < 0.001). Multivariate regression indicated that neuroticism (P = 0.03), agreeableness (P = 0.01), and conscientiousness (P = 0.03) had the ability to predict risk perception, while extraversion (P = 0.01) was able to predict problem-focused strategies. Conclusion: Based on our findings, other factors apart from improving the level of information are involved in this disease. Thus, information regarding the mental aspect of PLWH may find the missing link in this regard alongside treatment. Accordingly, the result obtained from this research can be used in preventive programs for PLWH.