Background and Objective: Today, much attention is being paid to the prevention of cardiovascular diseases. In some parts of the world, the rate of cardiovascular disease is low due to a Mediterranean diet containing olive oil. This systematic review examined the verses and traditions in order to express opinions on olive and compare it with the findings of modern medicine. Methods: This is a qualitative systematic review of studies  in which data  were collected from Qur'an, traditions, and related articles on the internet, limited to English and Persian and without time limitation by using the keywords olive, heart disease and Mediterranean diet. Results: This systematic review demonstrated that olive in the Quran is a clear sign to scientists. Moreover, its use is recommended in the authentic traditions. Conclusion: Based on the results, olive has been found to be effective in reducing mortality and preventing cardiovascular diseases.