A Life Cycle Assessment was carried out in order to assess the environmental performance of constructed wetland systems for winery wastewater treatment. In particular, six scenarios which included the most common winery wastewater treatment and management options in South-Western Europe, namely third-party management and activated sludge systems, were compared. Results showed that the constructed wetland scenarios were the most environmentally friendly alternatives, while the third-party management was the worst scenario followed by the activated sludge systems. Specifically, the potential environmental impacts of the constructed wetlands scenarios were 1.5-180 and 1-10 times lower compared to those generated by the third-party and activated sludge scenarios, respectively. Thus, under the considered circumstances, constructed wetlands showed to be an environmentally friendly technology which helps reducing environmental impacts associated with winery wastewater treatment by treating winery waste on-site with low energy and chemicals consumption.