In 1993, Isaias Pessotti, an already prominent name in the field of psychiatry, took a significant step in his work as a novelist with the publication of Aqueles cães malditos de Arquelau. The following year, Ivani C. Arantes Fazenda published Interdisciplinarity, presenting an instigating review on the question of method in the field of human sciences from the 1970s to that beginning of the last decade of the last century. This text reflects on Pessotti’s novel, stemming from all the provocation from Fazenda’s book, aiming, in particular, to highlight the problematic relationship between literary production and scientific production in the Latin American context.