We discuss a mixed-action approach in which sea quarks are regularised using non-perturbatively O(a) improved Wilson fermions, while a fully-twisted tmQCD action is used for valence quarks. In this setup, automatic O(a) improvement is preserved for valence observables, apart from small residual O(a) effects from the sea. A strategy for matching sea and valence is set up, and carried out for Nf = 2 + 1 CLS ensembles with open boundary conditions at several simulation points. The scaling of basic light-quark observables such as the pseudoscalar meson decay constant is studied, as well as the isospin splitting of pseudoscalar meson masses.