The mixing process greatly influence the mixing efficiency, as well as the quality and the price of the intermediate and/or the final product. Static mixer is used for premixing action before the main mixing process, for significant reduction of mixing time and energy consumption. This type of premixing action is not investigated in detail in the open literature. In this article, the novel numerical approach called Discrete Element Method is used for modelling of granular flow in multiple static mixer applications (1 - 3 Komax or Ross mixing elements were utilized), while the Computational Fluid Dynamic method was chosen for fluid flow modelling, using the Eulerian multiphase model. The main aim of this article is to predict the behaviour of granules being gravitationally transported in different mixer configuration and to choose the best configuration of the mixer taking into account the total particle path, the number of mixing elements and the quality of the obtained mixture. The results of the numerical simulations in the static mixers were compared to experimental results, the mixing quality is examined by RSD (relative standard deviation) criterion, and the effects on the mixer type and the number of mixing elements on mixing process were studied. The effects of the mixer type and the number of mixing elements on mixing process were studied using analysis of variance (ANOVA). Mathematical modelling is used for optimization of number of Ross and Komax segments in mixer in order to gain desirable mixing results. [Projekat Ministarstva nauke Republike Srbije, br. TR31055]