This paper is concerned with the nonfragile H∞ control problem for stochastic systems with Markovian jumping parameters and random packet losses. The communication between the physical plant and controller is assumed to be imperfect, where random packet losses phenomenon occurs in a random way. Such a phenomenon is represented by a stochastic variable satisfying the Bernoulli distribution. The purpose is to design a nonfragile controller such that the resulting closed-loop system is stochastically mean square stable with a guaranteed H∞ performance level γ. By using the Lyapunov function approach, some sufficient conditions for the solvability of the previous problem are proposed in terms of linear matrix inequalities (LMIs), and a corresponding explicit parametrization of the desired controller is given. Finally, an example illustrating the effectiveness of the proposed approach is presented.