"nBackground and Aims: Insolubility has been stated as one of the important characteristics of the materials which are used as sealers in the endodontic treatments. The aim of this study was to evaluate the solubility of four endodontic sealers (ZOE, Dorifill, AH26 and Tubliseal). "nMaterials and Methods: Five specimens from each sealer with similar size were prepared. After first weighing, the samples were stored individually in bottles containing 50 ml of distilled water at 37ºC. After 7 days, the specimens weighed and changes in the weight of each sample recorded with a digital scale. The data were analyzed by ANOVA and Post-hoc Tukey HSD tests. "nResults: The results of this study indicated that Dorifill had the maximum solubility among all sealers with weight loss of 2.8%. Tubliseal and ZOE showed the weight loss of 1.4% and 2.3%, respectively. AH26 showed weight gain of 1.9% during 7 days. There were no significant differences in the mean weight changes between Dorifill, Tubliseal and ZOE groups (P>0.05). A significant difference was found between the mean weight changes of AH26 and that of the other groups (P=0.000). "nConclusion: From the results of this study, all tested sealers were in the standard limit of solubility, and thus, it could confirm this physical property of sealers for clinical applications.