Radiation therapies are commonly used for malignant or metastatic brain tumors for curative and palliative use. The radiation-induced neurotoxicity includes both parenchymal and vascular damage. Here we report the case of a 43-year-old woman who developed Multiple sclerosis (MS) 9 months after she underwent the last session of radiotherapy for the diagnosed meningioma. Conventional doses of radiation might trigger MS.