The data consistently suggests that expansion and activation of beige/brite adipose tissue may possibly serve as a novel cure for obesity and obesity-related complications. Interestingly, besides well-known agents affecting adipocyte transformation, such as cold-induced sympathetic stimulation, the vast majority of biological systems (e.g. cardiovascular, endocrine, immune, musculoskeletal and central nervous system) also play a role in an adipose tissue modelling and maintaining energy homeostasis. Therefore, we decided to describe in detail the browning of the adipose tissue with a wide range of physiological factors associated with this process and to present the significant distinctions between “classical” brown and beige/brite adipocytes. Here, we review the current state of knowledge about browning phenomenon with regard to obesity prevention and/or management.