This research attempts to consider the relationship between "Islam" And "religious pluralism" through lexical and Quranic semantic of "Islam ". This word derived from "Selm" in Arabic and means subordination, humility and submission, because it does not have any insubordination and refusal. In Quranic verses " Islam" means "being surrendered to God and his commands", the commands that transmitted to people by messengers of God. Therefore, according to the verses of noble Quran, one of the most important submission conditions is the belief that Prophet Muhammad (pbuh), is the messenger of God. This reading is consistent with a meaning of the religious pluralism that emphasizes on rightfulness of Islam along the salvation of non Muslim people and , also, peaceful life with them, while is inconsistent with the definition that believe in plurality and equality of religions in rightfulness .