Multiple tuned mass dampers (MTMDs) distributed along height of a high-rise building are investigated for their effectiveness in vibration response control. A 76-storey benchmark building is modeled as shear type structure with a lateral degree of freedom at each floor, and tuned mass dampers (TMDs) are installed at top/different floors. Suitable locations for installing the TMDs and their tuning frequencies are identified based, respectively, on the mode shapes and frequencies of the uncontrolled and controlled buildings. Multimode control strategy has been adopted, wherein each TMD is placed where the mode shape amplitude of the building is the largest or large in the particular mode being controlled and tuned with the corresponding modal frequency. Newmark’s method is used to solve the governing equations of motion for the structure. The performance of the distributed MTMDs (d-MTMDs) is compared with single tuned mass damper (STMD) and all the MTMDs placed at top floor. The variations of top floor acceleration and displacement under wind loads are computed to study the effectiveness of the MTMDs in vibration control of the high-rise building. It is concluded that the d-MTMDs are more effective to control wind induced vibration than the STMD and the MTMDs placed at top floor.