Control valves play important roles in the control of the mixed-gas pressure in the combined cycle power plants (CCPP). In order to clarify the influence of coupling between the structure and the fluid system at the control valve, the coupling mechanism was presented, and the numerical investigations were carried out. At the same operating condition in which the pressure oscillation amplitude is greater when considering the coupling, the low-order natural frequencies of the plug assembly of the valve decrease obviously when considering the fluid-structure coupling action. The low-order natural frequencies at 25% valve opening, 50% valve opening, and 75% valve opening are reduced by 11.1%, 7.0%, and 3.8%, respectively. The results help understand the processes that occur in the valve flow path leading to the pressure control instability observed in the control valve in the CCPP.