Fertilization is an important management strategy of yams (Dioscorea spp.) especially when grown in degraded soils. A field study evaluated the leaf numbers, leaf area indices, crop growth, yields, and nitrogen (N) and potassium (K) use efficiencies of D. alata and D. rotundata in Côte d'Ivoire when grown in two contrasting soils with and without fertilizer. D. alata had a lower number of leaves per vine, although leaf area indices were higher, and the leaves were retained for a longer period than in D. rotundata. In all situations, the yields of D. alata were significantly higher, and fertilizers promoted growth of shoots, roots, tubers, and, thus, final yields especially in the low fertile savanna soil. The beneficial impact of fertilizer on yields was significantly lower in the fertile forest soils. The nutrient use agronomic efficiencies indicated the impact of both N and K in promoting yields especially under nonfertilized conditions.