The Permian from China has a well-known terrestrial record where approximately 30 tetrapod taxa, including several therapsids, have been described. However, the record of therocephalians in China has remained elusive. Shiguaignathus wangi gen. et sp. nov., discovered in the Member III of the Naobaogou Formation, Nei Mongol, China, is here described. This is the first therocephalian recovered from this fauna and only the second from the Permian of China. It is represented by a well-preserved robust snout of a medium-sized animal. This is the first akidnognathid reported from the Chinese Permian and only the second genus from Laurasia as one genus is known from Russia whereas the remaining members of the group are from the South African Karoo Basin. A phylogenetic analysis of therocephalians supports a basal position of S. wangi within Akidnognathidae, followed by the Russian Annatherapsidus. Akidnognathidae is the latest major group of therocephalian appearing in the fossil record, and one of the few that does not have species from South Africa representing its most basal members.