Parasitic disease of domestic and wild herbivores, hypodermosis is caused by the larval forms of warble fly species. This study aimed the emphasizing of hypodermosis prevalence in cattle from the south-western part of the country, in Mehedinţi district. Were been clinically examined for grub infestation 363 animals from 10 villages in Mehedinţi, 1-6 years aged, from particular breeders. Were been discovered 124 (34.15%) cattle with warbles on the back, flank and hump region, with a maximal average value of warbles on one animal of 21. From infected animals were been taken blood samples for haematological and biochemical examinations. The results of laboratory tests emphasized lower values of haematocrit, haemoglobin, eritrocytes number and a reduced level of seric glucose, proteins, albumins and calcium. All these results demonstrate the presence of anaemia and hyporeactivity state of parasitized animals.