According with the White Charter of Romanian SME-s 2007, Romanian integration in European Union was considered a great opportunity for the 46,67% of SME-s, just 9,18% of SME-s consider it like a major threatening. Romanian integration in European Union gave us much benefits and big responsibilities for all participants to this complex and long action, which is integration. The influence of integration in EU for SME-s was manifested in some special directions like: human resource, quality and competitiveness, ethics in business.