This paper is intended to evaluate the seismic performance of a twelve-story reinforced concrete moment-resisting frame structure with shear walls using 3D finite element models according to such seismic design regulations as Federal Emergency Management Agency (FEMA) guideline and seismic building codes including Los Angeles Tall Building Structural Design Council (LATBSDC) code. The structure is located in Seismic Zone 4, considered the highest-seismic-risk classification established by the U.S. Geological Survey. 3D finite element model was created in commercially available finite element software. As part of the seismic performance evaluation, two standard approaches for the structure seismic analysis were used; response spectrum analysis and nonlinear time-history analysis. Both approaches were used to compute inter-story drift ratios of the structure. Seismic fragility curves for each floor of the structure were generated using the ratios from the time history analysis with the FEMA guideline so as to evaluate their seismic vulnerability. The ratios from both approaches were compared to FEMA and LATBSDC limits. The findings revealed that the floor-level fragility mostly decreased for all the FEMA performance levels with an increase in height and the ratios from both approaches mostly satisfied the codified limits.