Chronic hand eczema (CHE) is a major burden for patients. Maintenance treatment involves prevention measures limiting detrimental behaviour and aggravating factors.To evaluate the effect of a standardised care program including therapeutic patient education (TPE) on hand care behaviours, clinical severity, quality of life and work productivity.A single-centre study was conducted prospectively. Together with the prescription of a topical steroid, patients participated in individual TPE sessions. Evaluations were performed initially and repeated three months after the therapeutic intervention. They included a structured analysis of hand care behaviours, the assessment of the mTLSS (modified Total Lesion Symptom Score), DLQI (Dermatology Life Quality Index) and WPAI (Work Productivity and Activity Impairment).Seventy-one patients were included (30 men, 42.3%). Three months after completion of the standardised care program (n=58), hand care behaviours such as hand washing and rinsing, hand drying, wearing protective gloves, using moisturizing creams and following specific treatments and recommendations for CHE improved significantly and were associated with a significant improvement in the mTLSS, DLQI and WPAI scores.TPE helps patients to change hand care behaviours, adopt skin protection measures and may improve CHE severity, quality of life and work productivity. This article is protected by copyright. All rights reserved.